Endocrine Abstracts

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...

Thyrotropin-secreting pituitary tumors are <1% of pituitary adenomas. Clinical manifestations are similar to other forms of hyperthyroidism. Most of them are diagnosed as macroadenoma (microadenomas <10%).Case 1: A 48 years old woman with menopause presented 6 years ago, consulting in 2009 for weight loss and palpitations. She had elastic goiter and distal tremor. Blood test: TSH 8.66 μUI/ml (0.2–4.2), FT4 4.7 ng/dl (0.7&#150...

Introduction: Data on body composition in patients with achondroplasia are scarce. The Phase Angle (PA) is a bioelectric measurement of our body cells. The PA is considered to be a global prognostic factor that gives information about cellular function in relation to body composition.Objectives: To describe body composition parameters PA, standardized PA (sPA), resistance (Rz), reactance (Xc), body cell mass (BCM), total body water (TBW), fat mass (FM), ...

Introduction: The European Society of Endocrinology Clinical Practice Guideline defines follow-up recommendations for AI based on the 1 mg overnight dexamethasone suppression test and the presence of associated comorbidities. Follow-up is not recommended for AI presenting serum cortisol levels post dexamethasone ≤1.8 μg/dl neither those presenting serum cortisol levels post dexamethasone between 1.9–5 μg/dl (defined as ‘possible autonomous cortisol se...

Introduction and aims: Autophagy is an essential process for cell homeostasis that implies recycling and degradation of damaged organelles and long-lived proteins. It is induced during caloric restriction (in order to obtain energy) or other stress-inducing conditions. Autophagy is initiated by autophagosome formation, a double-membrane vesicle which engulfs cellular components and delivers them for degradation by fusing with lysosomes. Thus, proper autophagy regulation favour...

Introduction: Somatostatin analogs (SS-analogs) are the treatment option when there is a persistent disease despite surgical intervention. They can be also recommended as a first line treatment if surgery is not appropriate (non-curative or contraindicated surgery).Objetive: To evaluate the effect of first-generation SS-analogs (lanreotide and octreotide) on tumour shrinkage and biochemical control in naive patients.Methods: We per...

Introduction: After menopause, an abrupt drop in estrogen levels happens, while ovary androgens secretion declines gradually with aging. This relative hyperandrogenism may lead to the development of hyperandrogenic symptoms. However, the development of marked hirsutism and/or symptoms/signs of virilization, make necessary a detailed study in order to rule out tumorous cause (from adrenal glands or ovaries).Case report: 58 years old woman with progressive...

IntroductionDyslipidemia is a major cardiovascular risk factor, being its detection and control essential due to risk of serious complications. Numerous trials have demonstrated its relationship with T2D, but it has not been so well studied in T1D.ObjectiveTo obtain information about relationship between dyslipidemia and T1D and analyze its prevalence and control in a sample of patients.<p class="abstext"...

Introduction: In May 2020, during the COVID-19 pandemic, the Spanish Group of Diabetes and Pregnancy published a consensus document establishing the alternative diagnostic criteria for gestational diabetes mellitus (GDM) in case of impossibility to perform the two-step traditional approach due to the COVID-19 sanitary emergency. This study aims to compare different characteristics of pregnant women who tested positive in the O’Sullivan test in the same pregnancy trimester...

Introduction: Overt thyroid dysfunction in pregnancy without an early diagnosis and treatment may lead to an increased risk of adverse maternal and fetal outcomes. In this study, our goal was to assess the results of the development of a laboratory alerting system for the diagnosis of thyroid dysfunction in the first trimester of pregnancy. Material and methods: Observational retrospective study evaluating clinical and biochemical data from pregnant wome...